Washington, D.C. 20549


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Ryan Jason

(Last) (First) (Middle)


(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
3. Issuer Name and Ticker or Trading Symbol
Magenta Therapeutics, Inc. [ MGTA ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
See Remarks
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
Chief Operating and Financial Officer Exhibit 24.1: Power of Attorney
No securities are beneficially owned.
/s/ Zoran Zdraveski, Attorney-in-Fact for Jason Ryan 01/04/2019
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
                               Power of Attorney

      Know all by these presents, that the undersigned hereby constitutes and
appoints each of  Zoran Zdraveski and  Cindy Driscoll, signing  singly, and with
full power  of substitution,  as the  undersigned's true  and lawful attorney-in
- fact to:

          (1) execute for and on behalf of the undersigned, in the undersigned's
          capacity as an officer and/or director of Magenta Therapeutics,  Inc.,
          a  Delaware  corporation  (the  "Company"),  from  time  to  time  the
          following Securities and Exchange Commission (the "SEC") forms:  Forms
          3,  4,  and 5  in  accordance with  Section  16(a) of  the  Securities
          Exchange Act of 1934, as  amended (the "Exchange Act"), and  the rules

          (2) do and perform any and all acts for and on behalf of the
          undersigned  which  may  be necessary  or  desirable  to complete  and
          execute any such Form 3, 4,  or 5, complete and execute any  amendment
          or amendments thereto, and timely file such form with the SEC and  any
          stock exchange or similar authority; and

          (3) take any other action of any type whatsoever in connection with
          the foregoing which, in the  opinion of such attorney-in-fact, may  be
          of benefit to, in  the best interest of,  or legally required by,  the
          undersigned, it being understood  that the documents executed  by such
 on behalf of  the undersigned pursuant to  this Power
          of Attorney shall  be in such  form and shall  contain such terms  and
          conditions as  such attorney-in-fact  may approve  in such attorney-in
          - fact's discretion.

       The undersigned hereby grants to each such attorney-in-fact full power
and  authority  to  do  and  perform any  and  every  act  and  thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the  rights
and  powers  herein  granted,  as  fully to  all  intents  and  purposes  as the
undersigned  might  or  could  do if  personally  present,  with  full power  of
substitution  or  revocation,  hereby ratifying  and  confirming  all that  such
attorney-in-fact, or  such attorney-in-fact's  substitute or  substitutes, shall
lawfully do or  cause to be  done by virtue  of this power  of attorney and  the
rights  and  powers  herein  granted.  The  undersigned  acknowledges  that  the
foregoing attorneys-in-fact, in serving in  such capacity at the request  of the
undersigned,  is  not  assuming,  nor  is  the  Company  assuming,  any  of  the
undersigned's responsibilities to comply with Section 16 of the Exchange Act.

       This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to  the
undersigned's holdings of and transactions in securities issued by the  Company,
unless earlier revoked by the undersigned  in a signed writing delivered to  the
foregoing attorneys-in-  fact. This  Power of  Attorney shall  expire as  to any
individual attorney-in-fact if such attorney-in-fact ceases to be an officer  of
the Company. This Power  of Attorney may be  filed with the SEC  as a confirming
statement of the authority granted herein.

       IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this  3rd day of January, 2019.

Employee: /s/ Jason Ryan
Printed Name: Jason Ryan